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Examples of potential inclusion criteria, if this approach were taken, are i) a score greater than 4 in the 12-question TSQ, a validated instrument used to assess hypothyroid symptomatology, or ii) an overall health-related QOL score using the ThyPRO-39 composite score of more than 32 (167)

Different eligible studies demonstrated that caffeine intake down-regulated the pro- and up-regulated the anti-inflammatory cytokines altered by stress [27, 83]

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doi:10.3390/ijms21176190 4.Pickart L, Vasquez-Soltero JM, Margolina A